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Central Role of Defective Interleukin-2 Production in the Triggering of Islet Autoimmune Destruction

2008· article· en· 710 citations· W2162675860 on OpenAlex· 10.1016/j.immuni.2008.03.016

Why is this work in the frame?

A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.

Canadian affiliationAn author listed a Canadian institution. This is the only route the usual frame has.
Canadian funderA Canadian agency funded it. The work may carry no Canadian affiliation at all.

Classifier prediction

metacan-v1-d91a1de5be90

Predictions imitate two machine teachers. Scores are not calibrated prevalence probabilities.

Classifier candidate
ObservationalBench or experimental
Classifier consensus
ObservationalBench or experimental
Teacher imitation scores

Codex

Bench or experimental0.412
Observational0.080
Other design0.007
Qualitative0.005
Not applicable0.004
Metaresearch0.001
Theoretical or conceptual0.001
Simulation or modelling0.001
Research integrity0.001
Science and technology studies0.000
Non-randomized trial0.000
Meta-epidemiology (broad)0.000
Randomized trial0.000
Meta-analysis0.000
Bibliometrics0.000
Scholarly communication0.000
Case report0.000
Meta-epidemiology (narrow)0.000
Open science0.000
Systematic review0.000

Gemma

Bench or experimental0.563
Observational0.256
Not applicable0.013
Qualitative0.004
Research integrity0.000
Metaresearch0.000
Theoretical or conceptual0.000
Science and technology studies0.000
Simulation or modelling0.000
Randomized trial0.000
Non-randomized trial0.000
Systematic review0.000
Meta-epidemiology (broad)0.000
Case report0.000
Open science0.000
Bibliometrics0.000
Scholarly communication0.000
Meta-epidemiology (narrow)0.000
Meta-analysis0.000

Machine scores (provisional)

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Opus teacher head0.013
GPT teacher head0.221
Teacher spread
0.208 how far apart the two teachers sit on this one work
Validation status
score_only:v0-immature-baseline verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Abstract

The dynamics of CD4(+) effector T cells (Teff cells) and CD4(+)Foxp3(+) regulatory T cells (Treg cells) during diabetes progression in nonobese diabetic mice was investigated to determine whether an imbalance of Treg cells and Teff cells contributes to the development of type 1 diabetes. Our results demonstrated a progressive decrease in the Treg cell:Teff cell ratio in inflamed islets but not in pancreatic lymph nodes. Intra-islet Treg cells expressed reduced amounts of CD25 and Bcl-2, suggesti…

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