Polyphosphazenes containing lactic acid ester and methoxyethoxyethoxy side groups — Thermosensitive properties and, in vitro degradation, and biocompatibility
Bibliographic record
Abstract
The thermosensitive and hydrolytic properties and biocompatibility of polyphosphazenes containing lactic acid ester and methoxyethoxyethoxy as co-substitutents were investigated. Depending on the type of lactic acid ester, these polyphosphazenes exhibited lower critical solution temperatures (LCST) (from 33 to 52 °C), which were almost concentration-independent in the range of 1.5 to 15 wt% of the polymers in aqueous solution. The salt effect on the thermosensitivity of the polymers was studied by measuring their LCST in aqueous solutions containing various salts. Bu4NBr and KI showed salting-in effects among the tested six salts, but NH4Br, NaBr, NH4Cl, and NaCl showed salting-out effects. Hydrolysis studies showed the rate of polymer hydrolysis decreased in the order of basic > acidic > neutral solution. The polyphosphazene with bulkier and more hydrophobic ester groups was more stable in hydrolysis. The results of a cytotoxicity study using an MTT assay method with HepG2 cell and K562/VCR cell showed that these polyphosphazenes and their degradation products were biocompatible. The thermoresponsiveness and biocompatibility of these biodegradable polyphosphazenes may favor the polymers as potential stimuli-responsive materials in biomedical applications.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".