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Record W2163268483 · doi:10.1016/j.juro.2013.08.004

Is Sperm DNA Integrity Assessment Useful?

2013· article· en· W2163268483 on OpenAlexaff
Ashok Agarwal, Armand Zini, Mark Sigman

Bibliographic record

VenueThe Journal of Urology · 2013
Typearticle
Languageen
FieldMedicine
TopicSperm and Testicular Function
Canadian institutionsMcGill University
Fundersnot available
KeywordsSpermDNA fragmentationIntracytoplasmic sperm injectionAndrologyMedicineGynecologyInfertilityBiologyPregnancyGenetics

Abstract

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No AccessJournal of UrologyOpposing Views1 Nov 2013Is Sperm DNA Integrity Assessment Useful? Ashok Agarwal, Armand Zini, and Mark Sigman Ashok AgarwalAshok Agarwal More articles by this author , Armand ZiniArmand Zini More articles by this author , and Mark SigmanMark Sigman More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2013.08.004AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail References 1 : Long-term effects of mouse intracytoplasmic sperm injection with DNA-fragmented sperm on health and behavior of adult offspring. Biol Reprod2008; 78: 761. Google Scholar 2 : Are sperm chromatin and DNA defects relevant in the clinic?. Syst Biol Reprod Med2011; 57: 78. Google Scholar 3 : Frequency and severity of sperm DNA damage in patients with confirmed cases of male infertility of different aetiologies. Reprod Biomed Online2010; 20: 759. Google Scholar 4 : Sperm chromatin structure assay as an independent predictor of fertility in vivo: a case-control study. Int J Androl2010; 33: e221. Google Scholar 5 : The effect of sperm DNA fragmentation on miscarriage rates: a systematic review and meta-analysis. Hum Reprod2012; 27: 2908. Google Scholar 6 : Oxidative deoxyribonucleic acid damage in sperm has a negative impact on clinical pregnancy rate in intrauterine insemination but not intracytoplasmic sperm injection cycles. Fertil Steril2011; 96: 843. Google Scholar 7 : The clinical utility of sperm DNA integrity testing: a guideline. Fertil Steril2013; 99: 673. Google Scholar 8 American Urological Association: The optimal evaluation of the infertile male: best practice statement revised (2010). Available at http://www.auanet.org/education/guidelines/male-infertility-d.cfm. Accessed July 5, 2013. Google Scholar © 2013 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetailsCited ByNiederberger C (2018) Re: Concordance among Sperm Deoxyribonucleic Acid Integrity Assays and Semen ParametersJournal of Urology, VOL. 195, NO. 2, (447-447), Online publication date: 1-Feb-2016.Niederberger C (2018) Re: Sperm Deoxyribonucleic Acid Fragmentation Assessment in Normozoospermic Male Partners of Couples with Unexplained Recurrent Pregnancy Loss: A Prospective StudyJournal of Urology, VOL. 196, NO. 4, (1232-1232), Online publication date: 1-Oct-2016. Volume 190Issue 5November 2013Page: 1645-1647 Advertisement Copyright & Permissions© 2013 by American Urological Association Education and Research, Inc.MetricsAuthor Information Ashok Agarwal More articles by this author Armand Zini More articles by this author Mark Sigman More articles by this author Expand All Advertisement PDF DownloadLoading ...

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.000
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesInsufficient payload (model declined to judge)
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Observational · Consensus signal: Observational
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.277
Threshold uncertainty score0.999

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0000.000
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0000.000
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.001
Insufficient payload (model declined to judge)0.0020.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.031
GPT teacher head0.301
Teacher spread0.270 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one teacher head, not a consensus.

Study designObservational
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations16
Published2013
Admission routes1
Has abstractyes

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