Formulation Development and Evaluation of Sodium Bicarbonate Tablets by Direct Compression Method
Bibliographic record
Abstract
Acidity is a worldwide problem caused by an imbalance between the acid secreting mechanisms of stomach and proximal intestine. It creates great trouble in the life of many people. An antacid neutralizes excess acidity and provide relief. Sodium bicarbonate is prescribed as an antacid to treat heartburn and acid indigestion condition. The main objective of the current work was to prepare sodium bicarbonate antacid tablets by direct compression method and to evaluate trial formulation with those available in the local market by pharmacopeial and nonpharmacopeial methods. Besides sodium bicarbonate, the excipients used were lactose, microcrystalline cellulose (Avicel) and magnesium stearate. The tablet weight set for compression was 318mg (±5%). After sieving through a 20 mesh screen, the powder was blended for five minutes and evaluated for its flow properties before compression on a single punch machine. The results revealed that the blend possessed good flow property, compressed easily and the resulting tablets complied all the standards and showed a close resemblance with sodium bicarbonate tablets which are available in the local market.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.007 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".