Physiological Correspondence Dictates Cortical Long-Term Potentiation and Depression by Thalamic Induction
Bibliographic record
Abstract
The auditory cortex exhibits frequency-specific plasticity over a life cycle. Although thalamocortical long-term potentiation (LTP) and depression (LTD) are components of a widely held model underlying the receptive field (RF) plasticity of cortical neurons, the model lacks direct supporting evidence. We show here that conventional high-frequency tetanic stimulation (TS) of the auditory thalamus induced long-term changes in cortical field excitatory postsynaptic potentials, including both LTP and LTD, in mice. Thalamic TS induced LTP when the stimulated thalamic and recorded cortical neurons were tuned to the same frequency and induced LTD when they were tuned to different frequencies. The thalamocortical LTP was N-methyl-d-aspartate-dependent, but the LTD also involved cortical γ-amino-butyric acidergic inhibition. Notably, the frequency-specificity of cortical LTP/LTD was in accordance with the frequency-specific plasticity of spike-based RFs of cortical neurons. Our results suggest that cortical LTP and LTD induced by thalamic induction can be a consequence of identical stimuli, occur in an input-specific manner, and account for frequency-specific remodeling of RFs of auditory cortical neurons.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.001 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".