Mid‐trimester serum relaxin concentrations and post‐partum pelvic floor dysfunction
Bibliographic record
Abstract
OBJECTIVES: To compare mid-trimester serum relaxin concentration (SRC) in primiparous women with or without pelvic floor dysfunction (PFD--stress urinary incontinence (SUI), genital prolapse). DESIGN: Nested observational cohort study. SETTING: Urogynecology clinic of affiliated University hospital. POPULATION: Primiparous women one to four years post-partum, who had, at time of index pregnancy, participated in a prospective observational study looking at mid-trimester serum relaxin and preterm delivery. METHODS: Relaxin had been obtained during the index pregnancy at 24 and 28 weeks. Primiparous women who had not given birth to a subsequent child were contacted and asked to return for a single visit assessing pelvic floor function. MAIN OUTCOME MEASURES: Pelvic Organ Prolapse Quantification system (POPQ) and Urogenital Distress Inventory (UDI-6). RESULTS: Fifty women participated, of whom 40 delivered vaginally. Seventeen (34%) women had prolapse and 23 (46%) had stress incontinence. Relaxin was slightly higher (not significantly) in women with PFD than in those without. Relaxin concentration declined significantly more rapidly from 24 to 28 weeks in incontinent women, after adjusting for baseline and obstetrical factors. CONCLUSIONS: In contrast to previous reports, mid-gestation relaxin tended to be higher and fall significantly faster in women with PFD. Acknowledging relaxin's effects on collagen turnover, our findings explore the association between childbirth and PFD.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.012 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.001 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.001 | 0.001 |
| Insufficient payload (model declined to judge) | 0.002 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".