Genome-Wide Survey of SNP Variation Uncovers the Genetic Structure of Cattle Breeds
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No Canadian affiliation. An affiliation-only frame — the usual design — would never have seen this work. It is one of the works that make the case for inverting the frame.
Abstract
The imprints of domestication and breed development on the genomes of livestock likely differ from those of companion animals. A deep draft sequence assembly of shotgun reads from a single Hereford female and comparative sequences sampled from six additional breeds were used to develop probes to interrogate 37,470 single-nucleotide polymorphisms (SNPs) in 497 cattle from 19 geographically and biologically diverse breeds. These data show that cattle have undergone a rapid recent decrease in effective population size from a very large ancestral population, possibly due to bottlenecks associated with domestication, selection, and breed formation. Domestication and artificial selection appear to have left detectable signatures of selection within the cattle genome, yet the current levels of diversity within breeds are at least as great as exists within humans.
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The record
- Venue
- Science
- Topic
- Genetic and phenotypic traits in livestock
- Field
- Biochemistry, Genetics and Molecular Biology
- Canadian institutions
- —
- Funders
- National Institute of General Medical SciencesBiotechnology and Biological Sciences Research CouncilAgricultural Research ServiceUniversità Cattolica del Sacro CuoreHolstein Association USANorges ForskningsrådInternational Livestock Research InstituteInternational Atomic Energy AgencyU.S. Department of AgricultureAgriculture and Agri-Food CanadaEmpresa Brasileira de Pesquisa AgropecuáriaMeat and Livestock AustraliaCooperative State Research, Education, and Extension ServiceNational Institutes of HealthAgResearch
- Keywords
- DomesticationBiologyGenetic diversityAnimal husbandrySelection (genetic algorithm)SNPGenetic variationGenomeEvolutionary biologyBovine genomeGeneticsSingle-nucleotide polymorphismGenotypeGeneEcologyAgricultureDemographyComputer science
- Has abstract in OpenAlex
- yes