Immunomodulating effects of egg yolk low lipid peptic digests in a murine model
Bibliographic record
Abstract
Abstract There is a close link between nutrition and immunity. Bioactive peptides derived from various protein sources have been demonstrated to exert immunomodulating effects. Those activated sequences may also be found in egg yolk. When administered in vivo to chicken, egg yolk digests prevented bacterial infections. Thus, egg yolk low lipid peptic digests' (EYLLPD) effects were studied in a murine model to elucidate their action's mechanism and immunomodulating capacity. The mucosal immune response was investigated by immunohistochemistry. IL-6 production was evaluated by ELISA. The results show that EYLLPD induces an immune response with an increase in IgA+ cells, while orchestrating the Th1/Th2 response. Furthermore, they reveal a potential role of the epithelium in the effects of EYLLPD at the epithelial surface, as suggested by the increase of the IL-6 secretion by small intestinal epithelial cells (SIEC). In summary, this study shows that EYLLPD enhances mucosal immune responses and that SIEC might have played an important role in preventing the bacterial infection.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".