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EVOLUTIONARY EPIDEMIOLOGY AND THE DYNAMICS OF ADAPTATION

2009· article· en· W2171049529 on OpenAlex
Sylvain Gandon, Troy Day

Why this work is in the frame

A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.

affAt least one author lists a Canadian institution in the pinned OpenAlex snapshot.
fundA Canadian funder is recorded on the work.

Bibliographic record

VenueEvolution · 2009
Typearticle
Languageen
FieldBiochemistry, Genetics and Molecular Biology
TopicEvolution and Genetic Dynamics
Canadian institutionsQueen's University
FundersCentre National de la Recherche ScientifiqueNatural Sciences and Engineering Research Council of CanadaCanada Research ChairsAgence Nationale de la Recherche
KeywordsBiologyAdaptation (eye)Evolutionary biologyEvolutionary dynamicsDemographyNeurosciencePopulation

Abstract

fetched live from OpenAlex

The mean fitness of a population, often equal to its growth rate, measures its level of adaptation to particular environmental conditions. A better understanding of the evolution of mean fitness could thus provide a natural link between evolution and demography. Yet, after the seminal work of Fisher and its renowned "fundamental theorem of natural selection," the dynamics of mean fitness has attracted little attention, and mostly from theoretical population geneticists. Here we analyze the dynamics of mean fitness in the context of host-parasite interactions. We illustrate the potential relevance of this analysis under different scenarios ranging from a simple situation in which a parasite evolves in a homogeneous host population to a more complex one with host-parasite coevolution. In each case, we contrast the effects of natural selection, recurrent mutations, and the change of the biotic environment, on the dynamics of adaptation. Decoupling these three components helps elucidate the interplay between evolutionary and ecological dynamics. In particular, it offers new perspectives on situations leading to evolutionary suicide. As mean fitness is an easily measurable quantity in microbial systems, this analysis provides new ways to track the dynamics of adaptation in experimental evolution and coevolution studies.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.000
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Theoretical or conceptual · Consensus signal: none
GenreCandidate signal: Empirical · Consensus signal: none
Teacher disagreement score0.882
Threshold uncertainty score0.258

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0000.000
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0000.000
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.009
GPT teacher head0.252
Teacher spread0.243 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it