[<sup>11</sup>C]Methyl‐losartan as a potential ligand for PET imaging angiotensin II AT<sub>1</sub> receptors
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Bibliographic record
Abstract
The renin‐angiotensin system regulates blood pressure via activation of the angiotensin II type 1 receptor (AT 1 R). The AT 1 R is involved in the pathology of cardiac and renal diseases such as heart failure and diabetic nephropathy. The aim of this study was to synthesize and characterize the O‐[ 11 C]methylated derivative of the clinically used AT 1 receptor blocker losartan as a novel AT 1 R PET imaging radioligand. [ 11 C]Methyl‐losartan was reliably synthesized ( n ≥ 40) via methylation of tetrazole‐protected losartan followed by deprotection using HCl in an overall yield of 30%–60% (decay‐corrected from [ 11 C]MeI). Radiochemical purity was >99% and specific activity 700–3600 mCi/µmol. Copyright © 2011 John Wiley & Sons, Ltd.
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Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it