Overall reductions in functional brain activation are associated with falls in older adults: an fMRI study
Bibliographic record
Abstract
Falls are a common geriatric condition, and while impaired cognitive function has been identified as a key risk factor, the neural correlates that contribute to reduced executive functioning and falls currently remain unknown. In this study, community-dwelling adults aged 65-75 years were divided into two groups based on their recent history of falls (fallers versus non-fallers). All participants completed the Flanker task during functional magnetic resonance imaging (fMRI). We examined the hemodynamic response of congruent and incongruent trials separately in order to separate the relative contribution of each trial type as a function of falls history. We found that fallers exhibited a smaller difference in functional activation between congruent and incongruent trials relative to non-fallers, as well as an overall reduction in level of blood-oxygen-level dependent response. Of particular note, the medial frontal gyrus - a region implicated in motor planning - demonstrated hypo-activation in fallers, providing evidence that the prefrontal cortex might play a central role in falls risk in older adults.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".