Bibliographic record
Abstract
Thrombin Activatable Fibrinolysis Inhibitor (TAFI), encoded by CPB2, cleaves carboxyl-terminal lysine residues from partially degraded fibrin, thus assisting in the attenuation of fibrinolysis. The finding of several new alternatively spliced (AS) CPB2 variants within numerous cell types suggests that AS is an important mechanism regulating CPB2 gene expression. This thesis investigated the extent of AS events occurring in various vascular and immune cells, and identified proteins translated from AS CPB2 mRNA. To determine whether a minigene approach could be used to model the cell-specific AS pattern that occurs endogenously, two minigene constructs were created. Real time RT-PCR analysis revealed that the pattern and extent of AS varies in a cell-specific manner. However, the minigenes were found to be unable to recapitulate the cell-specific splicing pattern of CPB2 that occurs endogenously. Metabolic labeling in conjunction with immunoprecipitation resulted in the detection of the Delta7 TAFI variant retained within HepG2 cells.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".