Hybrid Monoterpenoid Indole Alkaloids Obtained as Artifacts from Rauvolfia tetraphylla
Why is this work in the frame?
A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.
The three-model screen
all 1,000 screened works →All three models called this out of scope.
Natural products chemistry paper isolating indole alkaloid artifacts from Rauvolfia; the object is phytochemistry.
The paper reports the isolation and evaluation of natural products from a plant genus.
Natural-products chemistry of alkaloids from Rauvolfia.
Abstract
Rauvolfia genus of the Apocynaceae family, comprising about 60 species, is mainly distributed in America, Africa, Asia, and Oceania [ 1 ]. Plants of this genus are a rich source of monoterpenoid indole alkaloids, which have attracted great interests from biological and therapeutic aspects [ 2 – 5 ]. As part of a BioBioPha [ http://www.chemlib.cn ] objective to assemble a large-scale natural product library valuable in the discovery of new drug leads from nature, previous chemical study on the ethanolic extract of Rauvolfia tetraphylla had resulted in the isolation of five new indole alkaloids, rauvotetraphyllines A–E [ 6 ]. Further investigation of the remaining components led to the isolation of another five new alkaloids bearing an unusual 2,2-dimethyl-4-oxopiperidin-6-yl moiety, rauvotetraphyllines F–H ( 1 , 3 , 4 ), 17- epi -rauvotetraphylline F ( 2 ) and 21- epi -rauvotetraphylline H ( 5 ). The present paper describes the isolation, structure elucidation, and cytotoxic evaluation of the new compounds.
Stored with the screening record, where it is evidence for the labels above.
The record
- Venue
- Natural Products and Bioprospecting
- Topic
- Alkaloids: synthesis and pharmacology
- Field
- Pharmacology, Toxicology and Pharmaceutics
- Canadian institutions
- Francophone University Association
- Funders
- National Development and Reform Commission
- Keywords
- Indole testChemistryCytotoxicityIn vitroStereochemistryBiologyTraditional medicineBotanyBiochemistryMedicine
- Has abstract in OpenAlex
- yes