Sensitivity of CO<sub>2</sub>excretion to blood flow changes in trout is determined by carbonic anhydrase availability
Bibliographic record
Abstract
The blood transit time through the gills of rainbow trout (Oncorhynchus mykiss) was modified by manipulation of cardiac output (Vb). The experiments tested the hypothesis that efficiency of CO2 excretion is sensitive to changes in blood flow owing to chemical equilibrium limitations. An extracorporeal blood shunt was used to continuously monitor blood gases in fish in which Vb was elevated (by 13.3 +/- 2.4 ml x min(-1) x kg(-1)) by intravascular saline injection or reduced (by 10.8 +/- 1.8 ml x min(-1) x kg(-1)) by removal of plasma. The arterial partial pressure of CO2 (Pa(CO2); an index of CO2 excretion efficiency) was increased with elevated Vb and was decreased with reduced Vb such that the changes in Pa(CO2) exhibited a significant positive sigmoidal relationship with the changes in Vb (r2 =0.75; P < 0.05). In contrast, there was no significant relationship between changes in the arterial partial pressure of O2 (Pa(O2); an index of O2 uptake efficiency) and changes in Vb (r2 = 0.07; P > 0.05). The intravenous administration of carbonic anhydrase (CA; 10 mg/kg) before vascular volume loading eliminated the increase in Pa(CO2) with increased Vb that was observed in control fish.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".