Patient Characteristics Irritable Bowel Syndrome with Constipation (IBS-C)
Bibliographic record
Abstract
Purpose: Abdominal pain/discomfort, bloating and constipation are gastrointestinal dysmotility and sensory symptoms of IBS-C and are associated with impaired quality of life (QoL) and increased health care utilization. LOGIC is an ongoing, prospective, observational study to evaluate the Tx patterns and health outcomes of patients with IBS symptoms in Canada. Methods: 1,553 patients with IBS-type symptoms were enrolled from 147 community/specialist physician sites across Canada. Clinical data and patient-reported outcomes (PROs) were collected at baseline; PROs were completed at months 1, 3, 6, 9 and 12. QoL and patients' health state were assessed using IBS-QOL and EQ-5D, and work productivity using the WPAI:IBS. Resource utilization included number and type of physician visits, procedures and Tx. Results: Baseline data were obtained from 1,553 patients (1,321 [85%] women), mean age = 46 years, mean disorder duration = 11 years (1 month–69 years). Self-reported bowel patterns were predominantly constipation (39%) and alternating constipation/diarrhea (37%). The mean overall IBS-QOL (0–100 scale) was 66; food avoidance (52) and health worry (59) were the most serious concerns, followed by body image (61), dysphoria (67) and interference with activity (67). The WPAI:IBS indicated a 6% loss of work time, 34% impairment in overall work and 37% impairment in daily activities. In the preceding month, patients had on average, 0.76 consultations with a family doctor and 0.07 specialist visits, and fiber (30%), laxatives (28%) and analgesics (39%) were the most commonly reported non-prescription (Rx) medications used. At baseline, the most common Rx medications reported included tegaserod (26%) and pinaverium bromide (9%). Nearly two-thirds reported a history of undergoing a medical procedure, the most common being abdominal ultrasound (51%), barium X-ray (45%), and colonoscopy (35%). Conclusions: These baseline data are consistent with previous findings showing significant use of medications and healthcare resources with concomitant low QoL in patients with IBS symptoms. This study will follow patients for 1 year, providing insights into the assessment, Tx and outcomes of IBS symptoms in Canada.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.001 |
| Science and technology studies | 0.001 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.007 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".