Effect of N-acetylcysteine on microalbuminuria in patients with acute respiratory distress syndrome
Why this work is in the frame
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Bibliographic record
Abstract
Introduction: Acute respiratory distress syndrome (ARDS) is associated with enlarged permeability of respiratory capillaries resulting in interstitial edema and microalbuminuria. This study investigated the effect of early treatment with N-acetylcysteine (NAC) on microalbuminuria/creatinine ratio and clinical improvement in ARDS. Material and methods: Twenty-three patients with ARDS were randomly entered into two groups of study including regular therapy and regular therapy plus NAC. NAC was started with 150 mg/kg on the first day followed by 50 mg/kg at the second day. Urine sample was tested for microalbuminuria on 4, 6, 12, 24, 36, and 48 h post baseline. Results: No significant correlation was found between microalbumin/creatinine ratio (MACR) and acute physiology and chronic health evaluation (APACHE II) or PaO2/FiO2 ratio and blood pressure in each group. Non-survivors showed higher urine albumin creatinine ratio (ACR) and physiologic scores than survivors. The patients outcome who treated with NAC showed significant improvement comparing with controls. Conclusions: NAC improves global hypoxemia in the patients with acute lung injury. Improvement of oxidant/antioxidant balance by NAC increases the survival of patients with ARDS who are under oxidative crisis. Although limitations of this study do not let us to reach a conclusive decision but the impact of microalbominuria as a predictive of survival in ARDS patients receiving NAC seems essential. Conducting larger clinical trials are recommended.
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Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.001 |
| Science and technology studies | 0.000 | 0.002 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.001 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it