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Record W2186509442 · doi:10.7324/japs.2013.3918

Effect of Aframomum melegueta on carbon tetrachloride induced liver injury

2013· article· en· W2186509442 on OpenAlexfundno aff
Idoh Kokou, Karou Damintoti, Amégnona Agbonon, Yao Adjrah, Messanvi Gbeassor

Bibliographic record

VenueJournal of Applied Pharmaceutical Science · 2013
Typearticle
Languageen
FieldPharmacology, Toxicology and Pharmaceutics
TopicDrug-Induced Hepatotoxicity and Protection
Canadian institutionsnot available
FundersInstitut national de la recherche scientifique
KeywordsCarbon tetrachlorideZingiberaceaeTraditional medicineLiver injuryChemistryMedicinePharmacologyOrganic chemistryRhizome

Abstract

fetched live from OpenAlex

This present study was performed to evaluate the hepatoprotective effect of Aframomum melegueta seeds, used as spicy in the traditional conditions.The hepatoprotective activity of the seeds of A. melegueta at 100 and 150 mgEq.pp/kg,administered orally, was assessed using carbon tetrachloride-induced (CCl4) liver damage (1 ml/kg bw 1:1 CCl4 and corn oil).The results obtained from this study show that A. melegueta produced a significant decrease in serum transaminases and alkaline phosphatase.At the dose of 150 mg Eq.pp/kg, A. melegueta induced a significant increase in serum total proteins.Liver and serum antioxidant potentials were also significantly increased.Those results indicate that A. melegueta seeds protect the liver against toxicity induced in this study.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.000
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Bench or experimental · Consensus signal: Bench or experimental
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.001
Threshold uncertainty score0.004

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0000.000
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0000.000
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0010.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.074
GPT teacher head0.424
Teacher spread0.350 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designBench or experimental
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations8
Published2013
Admission routes1
Has abstractyes

Explore more

Same venueJournal of Applied Pharmaceutical ScienceSame topicDrug-Induced Hepatotoxicity and ProtectionFrench-language works237,207