Bibliographic record
Abstract
【目的】14-3-3ηは200以上の細胞内タンパクに関係する細胞内シャペロンである，関節リウマチ（RA）では関節液および血清中にも出現する．そこで14-3-3ηに注目し，RA治療開始後の臨床的アウトカムとの関係を検討した．【成績】当科で治療導入したRA患者99（adalimumab; ADA 49，tocilizumab; TCZ 50）例で，Baseline（BL）と1年後の血清14-3-3ηをELISA法で測定し，BLと1年後の種々の臨床的指標との関係を検討した．【結果】背景中央値は年齢63歳，罹病期間76ヶ月，DAS28ESR 5.3，RF陽性82％，ACPA陽性90％で，ADA群とTCZ群で罹病期間，MTX併用率，Sharp-vdH score（SHS）で差があった．BLにおける14-3-3η濃度は，BLの疾患活動性（DAS28, CDAI, SDAI），急性炎症反応（CRP, ESR），関節破壊（SHS），血清反応（RF濃度，ACPA濃度）のいずれとも有意に相関した．また治療によりBL 0.70 ng/mlから1年後0.37 ng/mlにに低下した（p < 0.0001）．1年後のDAS28-ESR寛解（η 2.6）に対するBL 14-3-3ηカットオフ値（0.32 ng/ml）をROC解析により設定し層別化すると，1年後の寛解達成率はADAではBL 14-3-3η低値群40％（8/12），高値群59％（12/29）であった（p = 0.20）が，TCZでは低値群77％（10/13），高値群37％（10/27）とBL14-3-3η低値群で有意（p = 0.0007）に高かった．【結論】BL 14-3-3η低値の場合，tocilizumabによる1年後の臨床的寛解を達成しやすいこと示された．
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.004 | 0.015 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.001 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.001 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.001 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".