Interaction of cyclooxygenase 2 genotype and smoking habit in Taiwanese lung cancer patients.
Bibliographic record
Abstract
AIM: The aim of this study was to evaluate the association and interaction of genotypic polymorphisms in the cyclooxygenase 2 (Cox-2) gene with smoking habits with lung cancer patients in Taiwan. Six polymorphic variants of Cox-2 were analysed in association with their effect on lung cancer susceptibility, and their joint effects with smoking habits on lung cancer risk is discussed. MATERIALS AND METHODS: Three hundred and fifty-eight patients with lung cancer and 716 healthy controls from the China Medical Hospital in central Taiwan were genotyped. RESULTS: The Cox-2 intron 6 (rs2066826) genotypes were distributed differently between the lung cancer and control groups. The A allele of Cox-2 intrin 6 was found more frequently in the cancer patient group than in the controls. Furthermore, the interactions of smoking with genetic factors were significant for the Cox-2 intron 6 genotypes. Patients who smoked and had the Cox-2 intron 6 AG or AA genotype had an increased risk of 2.21 (95% confidence interval=1.53-3.27) for developing lung cancer. CONCLUSION: These results provide evidence that the A allele of Cox-2 intron 6 may be associated with the development of lung cancer and may be a useful marker for early detection and treatment of lung cancer.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".