OC18.03: Fetal hemodynamic parameters for prediction of neonatal outcome in Twin–twin transfusion syndrome treated by laser photocoagulation
Bibliographic record
Abstract
To determine the prognostic value of fetal Doppler and echocardiographic parameters in neonatal outcome after laser coagulation in monochorionic pregnancies complicated by Twin–twin transfusion syndrome (TTTS). To evaluate whether hemodynamic changes, pre and post laser photocoagulation, predict the neonatal survival. Fetal echocardiography and outcome data of consecutive cases of TTTS treated by laser photocoagulation were retrospectively reviewed. Hemodynamic and cardiac function parameters were collected pre and post treatment. Between February 2006 and January 2015, 105 laser coagulations were performed. Due to the retrospective nature of this study, fetal echocardiography pre and post laser intervention were available in only 68 cases. Survival rates were 17%, 22% and 61% for zero, one or two twins respectively. At least one twin was delivered alive in 83% of the pregnancies. The mean gestational age at surgery was 21 weeks (range 16–26). The mean age at birth in cases with at least one live fetus was 32 weeks (range 23–41). This study found than preoperative predictors for survival rate at birth and after neonatal period, recipient peak systolic velocity of middle cerebral arteria (PSV-MCA) (p = 0.025 and p = 0.023), especially for recipient (p = 0.017 and p = 0.002) and recipient right ventricular myocardial performance index (MPI) (p = 0.004 and p = 0.007), especially for recipient (p = 0.041 and p = 0.02). The preoperative CHOP cardiovascular score was related to survival recipient at birth (p = 0.045) and to neonatal survival (p = 0.046). Donor survival was related to preoperative donor PSV-MCA (p = 0.011). The postoperative predictor for survival rate at birth and after neonatal period were pulsatility index of recipient Ductus Venosus (PIDV) (p = 0.008 and p = 0.001), especially for recipient (p = 0.008 and p = 0.003). The major hemodynamic predictors of neonatal survival found in this study were preoperative recipient PSV-MCA, recipient right ventricular MPI and postoperative recipient PIDV.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.009 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.001 | 0.001 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".