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Treatment of infertility does not increase the risk of ovarian cancer among women with a BRCA1 or BRCA2 mutation

2015· article· en· W2199916845 on OpenAlexafffund
Jacek Gronwald, Karen Glass, Barry P. Rosen, Beth Y. Karlan, Nadine Tung, Susan L. Neuhausen, Pål Møller, Peter Ainsworth, Ping Sun, Steven A. Narod, Jan Lubiński, Joanne Kotsopoulos, Henry T. Lynch, Cezary Cybulski, Charmaine Kim‐Sing, Susan Friedman, Leigha Senter, Jeffrey N. Weitzel, Christian Singer, Charis Eng, Gillian Mitchell, Tomasz Huzarski, Jeanna McCuaig, Andrea Eisen, Dawna Gilchrist, Joanne L. Blum, Dana Zakalik, Tuya Pal, Mary B. Daly, Barbara L. Weber, Carrie Snyder, Taya Fallen, Albert E. Chudley, John Lunn, Talia Donenberg, Raluca Kurz, Howard M. Saal, Judy E. Garber, Gad Rennert, Kevin Sweet, Christine Rappaport, Edmond G. Lemire, Dominique Stoppa-Lyonnet, Olufunmilayo I. Olopade, Sofía D. Merajver, Louise Bordeleau, Carey A. Cullinane, Eitan Friedman, Wendy McKinnon, Marie Wood, Daniel Rayson, Wendy S. Meschino, Josephine Wagner Costalas, Robert E. Reilly, Susan T. Vadaparampil, Kenneth Offit, Noah D. Kauff, David Euhus, Ava Kwong, Claudine Isaacs, Fergus J. Couch, Siranoush Manoukian, Tomasz Byrski, Christine Elser, Seema Panchal, Susan Randall Armel, Rochelle Demsky, Sonia Nanda, Kelly Metcalfe, Aletta Poll, William D. Foulkes, André Robidoux, Ellen Warner, Lovise Mæhle, D. Gareth Evans, Barbara Pasini, Ophira Ginsburg, Stephanie A. Cohen, Anna Jakubowska, Janice Little

Bibliographic record

VenueFertility and Sterility · 2015
Typearticle
Languageen
FieldMedicine
TopicOvarian cancer diagnosis and treatment
Canadian institutionsCReATe Fertility CentreWomen's College HospitalUniversity of Toronto
FundersNational Institutes of HealthNational Cancer InstituteCancer Care Ontario
KeywordsInfertilityMedicineOdds ratioConfidence intervalBRCA mutationGynecologyOvarian cancerFertilityObstetricsOncologyLogistic regressionCancerInternal medicinePregnancyPopulationBiologyGenetics

Abstract

fetched live from OpenAlex
No abstract in any covered source. Its absence is recorded, not treated as a negative.

No abstract. This is not a gap in this database; OpenAlex has none either. 23.3% of the frame is in this state, and the screen finds HALF as much metaresearch here, so the absence is a measured bias rather than a missing field.

How this classification was reachedexpand

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.000
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Observational · Consensus signal: Observational
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.108
Threshold uncertainty score0.978

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0000.000
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0010.000
Bibliometrics0.0000.000
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.031
GPT teacher head0.285
Teacher spread0.254 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one teacher head, not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designObservational
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations69
Published2015
Admission routes2
Has abstractno

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