Hydration of Hydrophobic Iron–Carbonyl Homopolymers via Water–Carbonyl Interaction (WCI): Creation of Uniform Organometallic Aqueous Vesicles with Exceptionally High Encapsulation Capacity
Bibliographic record
Abstract
Metal–carbonyl homopolymers (PFpPs) are hydrophobic but able to self-assemble in water into uniform and stable colloids. Hydrodynamic radius ( R h ) of the colloids varies from 42 to 77 nm depending on preparation conditions. Light scattering, TEM, and AFM analyses of the colloids indicate that the colloids have a vesicular morphology with membrane thickness of ca. 3.0–4.0 nm. This thin membrane is, however, relatively rigid compared to conventional polymersomes. FT-IR and NMR analyses indicate that water–carbonyl interactions (WCI) is a motif responsible for the self-assembly and colloidal stability. By using nanoprecipitation encapsulation technique, PFpP vesicles can enclose hydrophilic molecules with extremely high encapsulation efficiency (EE) and loading capacity (LC). This work opens up a new research topic on hydration driven self-assembly and resolves a long-standing challenge of low EE and LC for the encapsulation of hydrophilic molecule via nanoprecipitation using amphiphilic molecules.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".