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Record W2208395593 · doi:10.1017/cjn.2015.162

Novel VCP mutation associated with CMT2 phenotype

2015· article· en· W2208395593 on OpenAlexvenueno aff
BK Steven

Bibliographic record

VenueCanadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques · 2015
Typearticle
Languageen
FieldNeuroscience
TopicHereditary Neurological Disorders
Canadian institutionsnot available
Fundersnot available
KeywordsProbandHereditary spastic paraplegiaAmyotrophic lateral sclerosisMedicinePhenotypeExome sequencingFrontotemporal dementiaPathologyMutationUpper motor neuronGeneticsDiseaseDementiaBiologyGene

Abstract

fetched live from OpenAlex

Background: Charcot-Marie-Tooth (CMT) neuropathy is an increasingly polygenic disorder which limits clinical diagnoses due to phenotypic overlap resulting from the common final pathway of length-dependent axonal degeneration. The proband exhibited features of an axonal neuropathy manifesting upper and lower extremity distal amyotrophy, mild sensory loss, absent upper motor neuron findings, and mild hyperCKemia. Methods: Whole-exome sequencing (WES) was performed after failure to identify the familial variant with sequencing of multiple discrete CMT2 genes. Results: A novel VCP mutation (c.511A>C;p.Ser171Arg) was identified. This mutation segregated with an affected brother and father. All manifested a CMT2 phenotype with motor predominance. Further investigation of the proband revealed 1) a muscle biopsy with no inclusions or myopathic changes, 2) a skeletal survey negative for lucencies and hyerostoses, and 3) normal cognitive function. Conclusions: Mutations in valosin-containing protein (VCP) are associated with distinct neurologic phenotypes including 1) inclusion body myopathy, Paget disease, and frontotemporal dementia, 2) hereditary spastic paraplegia, and 3) amyotrophic lateral sclerosis. Recently, CMT2 has been described as a VCP-associated phenotype. This is the second report of a peripheral neuropathic phenotype resulting from a mutation in the VCP gene. The clinical presentation in this family suggests a unique clinical-biochemical phenotype consisting of motor-predominant CMT2 with mild hyperCKemia.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.005
metaresearch head score (Gemma)0.022
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesMetaresearch, Meta-epidemiology (narrow), Science and technology studies
Consensus categoriesScience and technology studies
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Observational · Consensus signal: none
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.539
Threshold uncertainty score1.000

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0050.022
Meta-epidemiology (narrow)0.0010.000
Meta-epidemiology (broad)0.0010.000
Bibliometrics0.0010.003
Science and technology studies0.0030.010
Scholarly communication0.0010.002
Open science0.0030.000
Research integrity0.0000.002
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.080
GPT teacher head0.276
Teacher spread0.195 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; both teacher heads agree on what is shown here.

Study designObservational
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations0
Published2015
Admission routes1
Has abstractyes

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