Selective Cooling of the Brain in Newborn Piglets and Rabbits Using a Novel Nasopharyngeal Method
Bibliographic record
Abstract
Mild hypothermia has become an effective neuroprotective strategy following head trauma, cardiac arrest and neonatal asphyxia. However, cooling the whole body below 33-34°C can induce severe complications; therefore, selective brain cooling (SBC) could minimize adverse effects by maintaining core body temperature at normal values over an extended period of time. Recently, we developed a novel method of SBC and demonstrated its safety and efficacy in a piglet model. the method was based on spraying room temperature or cold air into the nostrils at different flow rates. Pigs possess a carotid rete (a set of small parallel arteries) which is surrounded by the cavernous sinus; together these serve as an effective heat exchanger for the brain. However, in mammals in which the carotid rete is missing such as rabbits and humans, some suggest that there is no effective heat exchange in the cavernous sinus and, consequently, SBC is not efficient in these species.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.005 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.001 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".