DNA Strand Breaks Induced by 0–1.5 eV UV Photoelectrons under Atmospheric Pressure
Bibliographic record
Abstract
Vacuum experiments with monoenergetic low-energy electrons (LEEs) impacting on biomolecules have revealed basic mechanisms of radiobiological damage. To move closer to cellular conditions, we explore the possibility of damaging DNA at standard atmospheric pressure with electrons of 0–1.5 eV. These electrons are produced by UV light incident on a tantalum or n-Si substrate, onto which a five-monolayer film of DNA is deposited. Total conformational damage, cross-links, and double- and single-strand breaks (SSBs) are measured as a function of LEE fluence. The photoelectron energy distribution can be modified by changing the work function of the substrate or the photon energy. In a N 2 atmosphere with a tantalum substrate, the yields of SSBs (5 ± 2 × 10 –14 electron –1 molecule –1 ) and their number per energy deposited (46 ± 36 × 10 –4 /eV) are in good agreement with those obtained, under similar conditions, by monoenergetic 0.5–1.0 eV electron impact in vacuo and 1.5 KeV X-ray photoelectrons at atmospheric pressure, respectively. SSB is the only conformational change detected; it results from electron capture on a DNA base followed by dissociative electron attachment at the phosphate unit.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".