Nursing support program to decrease or prevent side effects of pegylated liposomal doxorubicin (PLD) in patients with recurrent epithelial ovarian cancer (REOC)
Bibliographic record
Abstract
8198 Background: A significant long-term survival with PLD compared to topotecan was recently reported in a phase III randomized study of women with REOC (Gyn. Oncol. 2004). PLD is known to be relatively less toxic than topotecan and conventional doxorubicin, however side effects such as palmar-plantar erythrodysesthesia (PPE) may lead to sub-optimal drug exposure and treatment discontinuation. Methods: A nursing support program was created to determine if patient education and proactive nursing care could improve treatment outcomes by decreasing the occurrence and/or severity of PLD-related side effects. Patients who agreed to participate in the program were: educated about potential toxicities associated with PLD, received written instructions on the prevention and management of side effects and were provided with a diary to record symptoms and interventions. Results: A total of 112 ovarian cancer patients who relapsed after one or more prior therapies were accrued in 8 different centers. PLD was administered as 2nd, 3rd and ≥ 4th line therapy in 51%, 34% and 15% of patients, respectively. The majority of patients (85%) received a Taxol/platinum combination as 1st line therapy. The median patient age was 62 years (32–87). The average dose of PLD was 40.4 mg/m2 (35–50) every 28 days for an average of 4.01 cycles (1–23). Efficacy was evaluated using clinical symptoms and/or radiological evaluation. A majority of patients (69%) benefited from therapy characterized as disease stabilization or better. Overall the frequency of adverse events, in these heavily pretreated patients, was similar to that observed in a previous phase III clinical trial (Gordon JCO 2001) where patients had received only one prior therapy. However, the incidence of some grade 3/4 toxicities was substantially decreased, thus grade 3/4 PPE and mucositis were reduced from 21% to 4% and 8% to 3%, respectively. Conclusions: The nursing support program helped to reduce the severity of PPE and mucositis in patients receiving PLD for recurrent epithelial ovarian cancer. No significant financial relationships to disclose.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.002 | 0.004 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.002 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".