Abstract P3-12-02: Lifestyle interventions combined with acupuncture-like transcutaneous electrical nerve stimulation in managing vasomotor symptoms induced by breast cancer treatment: Results of a phase 2 randomized controlled trial
Bibliographic record
Abstract
Abstract Background: Women with breast cancer can experience significant treatment induced vasomotor symptoms (TIVS). Non-hormonal strategies for TIVS (e.g. acupuncture, Venlafaxine) provide some relief but may be intolerable because of the invasive nature of the treatment and possible side effects. As such, women often prefer lifestyle strategies (LS) that can be self-administered. Acupuncture-like transcutaneous electrical nerve stimulation (ALTENS) is a non-invasive needleless technique that uses specific electrical parameters to stimulate selected acupoints to achieve clinical response with minimal toxicity. ALTENS can be administered with minimal training. It is amenable to quality assurance and can allow for self treatment by women. This study aimed to evaluate the efficacy of ALTENS in addition to LS in relieving TIVS in women with breast cancer. Methods: Eligible subjects were postmenopausal women with Stages 0-3 breast cancer who had completed cancer treatment and were experiencing hot flashes for ≥ one month with a Hot Flash Score (HFS) ≥15 in one week prior to consent. Anti-estrogen therapy was permitted. Non-hormonal drug therapies were prohibited. Subjects were randomized to either LS (control) or LS with concurrent ALTENS (combined). LS consisted of standardized lifestyle strategies (e.g. environmental control, managing hot flash triggers) counseling delivered by a specially trained nurse practitioner at week 0 with reinforcing counseling at weeks 12 and 24. ALTENS was given twice weekly for 12 treatments over an 8-week period. The HFS, Hot Flash Related Daily Interference Scale and the Short Form version 2 health survey were administered at weeks 0, 12 and 24. Heart rate variability was measured at weeks 0 and 12. The primary study endpoint was the number of responders, defined as women who had > 50% reduction in their HFS between weeks 0 and 12. Results: 71 eligible subjects with a median age of 52 (range: 40-87) were randomized to combined arm (n=36) and control (n=35). At 12 weeks there were 11 (30.6%) responders in the combined arm versus 2 (5.7%) in the control (p=0.012).The results at 24 weeks were 14 versus 4, respectively (p=0.013). Arms were balanced for anti-estrogen use. Two subjects chose to discontinue ALTENS after experiencing symptoms improvement. There were no serious adverse events. Conclusion: ALTENS in combination with lifestyle strategies is a promising non-pharmacologic approach that showed improvement in managing treatment induced vasomotor symptoms in women with breast cancer. Our trial results support its evaluation in phase 3 studies. Citation Format: Margaret Forbes, Raimond Wong, Stephen M Sagar, Jim A Julian, Mark N Levine, Joseph Hayward. Lifestyle interventions combined with acupuncture-like transcutaneous electrical nerve stimulation in managing vasomotor symptoms induced by breast cancer treatment: Results of a phase 2 randomized controlled trial [abstract]. In: Proceedings of the Thirty-Seventh Annual CTRC-AACR San Antonio Breast Cancer Symposium: 2014 Dec 9-13; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2015;75(9 Suppl):Abstract nr P3-12-02.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.003 | 0.003 |
| Meta-epidemiology (narrow) | 0.002 | 0.001 |
| Meta-epidemiology (broad) | 0.004 | 0.004 |
| Bibliometrics | 0.001 | 0.001 |
| Science and technology studies | 0.001 | 0.001 |
| Scholarly communication | 0.001 | 0.001 |
| Open science | 0.001 | 0.000 |
| Research integrity | 0.003 | 0.003 |
| Insufficient payload (model declined to judge) | 0.014 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".