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Intestinal damage in weanling pigs following a nutritional insult is transient

2012· article· en· W2233033437 on OpenAlexaff
Crystal L Levesque, K. de Ridder, L. Skinner, Cornelius FM de Lange

Bibliographic record

VenueThe FASEB Journal · 2012
Typearticle
Languageen
FieldAgricultural and Biological Sciences
TopicAnimal Nutrition and Physiology
Canadian institutionsUniversity of Guelph
Fundersnot available
KeywordsWeanlingJejunumIleumCryptAnimal scienceInternal medicineBiologyEndocrinologyMedicineAndrology

Abstract

fetched live from OpenAlex

Forty pigs were used to evaluate the long‐term effect of nutritional insult on measures of intestinal development in weanling pigs. Pigs were weaned at 21±2 days of age and fed diets ad libitum containing either high (H) or low (L) quality protein sources for 6 wks. Growth performance was monitored weekly. Pigs were killed at wk 2 and 4. Sections of proximal jejunum and distal ileum were taken for histology and ileal digesta was sampled. Pigs on L had lower ( P = 0.002) daily gain in wks 1–3 but not different in wks 4–6 compared to H pigs. Similarly, feed efficiency in pigs on L was lower ( P < 0.05) during wks 2–3 but not different in wks 4–6. In the proximal jejunum, villus height was lower ( P = 0.03) at wk 2 in pigs on L (356 vs 427 μm) but not different at wk 4 (527 vs 492 μm). There was no difference in crypt depth but villus height:crypt depth ratio increased ( P = 0.04) from wk 2 to wk 4 (1.7 vs 2.2) in pigs on L and did not change in pigs on H (2.3 vs 2.5). Pigs on H tended to have a greater ( P < 0.17) proportion of proliferating cells in the jejunum at wk 2 and 4. In wk 2, digesta amine concentration was higher ( P = 0.06) in pigs on L. Diet quality did not impact gut morphology or cell proliferation at the distal ileum. Low quality protein sources reduced overall growth performance in weanling pigs but the negative effect of protein quality on gut morphology was transient. Recovery in feed utilization in pigs on L was likely due to rapid recovery of intestinal function.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.000
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Bench or experimental · Consensus signal: Bench or experimental
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.002
Threshold uncertainty score0.006

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0000.000
Meta-epidemiology (narrow)0.0010.000
Meta-epidemiology (broad)0.0010.001
Bibliometrics0.0010.000
Science and technology studies0.0000.001
Scholarly communication0.0000.001
Open science0.0000.000
Research integrity0.0010.001
Insufficient payload (model declined to judge)0.0020.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.036
GPT teacher head0.249
Teacher spread0.213 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designBench or experimental
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations0
Published2012
Admission routes1
Has abstractyes

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