Abstracts for the 35th Human Genetics Society of Australasia Annual Scientific Meeting, Gold Coast, Australia July 31–August 3, 2011
Bibliographic record
Abstract
It is now accepted that a central step in the development of most if not all cancers is impairment of apoptosis, the natural process of cell death. This essential biological process is generally controlled by the relative abundance and interactions of three factions of the Bcl-2 protein family. Apoptosis is signally by distant Bcl-2 relatives, the 'BH3-only proteins', but requires their activation of the more closely related Bax or Bak, which then oligomerize and elicit cell death by disrupting the mitochondrial outer membrane, thereby unleashing a proteolytic cascade. Bcl-2 and its closest relatives (e.g., Bcl-xL and Mcl-1) prevent apoptosis by preventing the activation and oligomerization of Bax and Bak. The steps by which the apoptotic switch is flipped are now being revealed. Apoptosis is constrained in many cancer cells; for example, by elevated expression of Bcl-2, reducing the effectiveness of conventional cancer therapies. Hence, there is now intense interest in the prospect of developing, as novel anti-cancer agents, small synthetic molecules that antagonize one of more pro-survival family members as do their natural ligands, the BH3-only proteins. The first of these 'BH3 mimetics', such as Abbott's ABT-737, which targets three of the pro-survival proteins, have shown considerable promise in pre-clinical studies and also encouraging results in the first clinical trials, particularly in cancers where Bcl-2 is overexpressed.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.002 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.001 | 0.001 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.001 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".