Clinical activity of celecoxib (CXB) in metastatic malignant melanoma (MMM)
Bibliographic record
Abstract
7555 Background: COX-2 is demonstrable by IHC in most primary MM, and by mRNA/protein studies in MM cell lines (Denkert, Cancer Res., 2001). Effects of COX-2 therapy (Rx) in MM include decreased endothelial cell migration, dose/time dependent decreases in invasiveness and collagenase IV production, fewer lung metastases post i.v. tumor cell inj., and reduced Matrigel invasion in MM cell lines. Analyses of COX-2 expression during melanoma progression suggest that COX-2 has a functional role (Goulet et al, Cancer Biol Ther., 2003). Following the observed regression (?“spontaneous”) of lung metastases in a MMM pt who received CXB for acute gout (http://bmj.bmjjournals.com/cgi/eletters/325/7371/26644), CXB was offered to suitable pts. who had either no/minor symptoms, or had failed other Rx. CXB is presently approved by Health Canada for familial adenomatous polyposis coli. Methods: Eligibility; age >16 yrs, surgically incurable recurrent MM. Pts. with prior IFN (adjuvant), RT, chemoRx (CT), BioCT were included. Treatment; CXB 200mg daily, Rofecoxib 12.5mg daily for 1 sulfa-allergic pt., and continued until progression (PD). Results: From May 2000 to Aug 2004, 24 pts (7 F, 17 M), 22 cutaneous, 1 anal canal, 1 choroidal MM, median age 58.4 yrs (range 24 - 85), distant mets. (N = 23), unresectable regional mets. (N = 1), were treated. Median diameter of largest metastasis was 31 mm (range 0 - 110) at start of CXB (0 = non measurable pleural effusion). Median follow-up time for living pts. is 10.3 mo. (range 3.6 - 55.2). Prior therapy; RT (N = 8), DTIC (N = 4), IFN (N = 2), BioCT (N = 1), no prior Rx (N = 12), no prior systemic Rx (NPSRx, N = 16). Two pts. were CXB - intolerant and stopped within 2 wks. Tumor regressions were seen in 5 pts; 2 CR in small volume lung mets. (1 had previous Cancervax then BioCT, 1 NPSRx), mixed stable/PR in 3 NPSRx pts. (1 bulky metastatic choroidal MM, 1 multiple lung mets., 1 bilat. neck nodes) [images to be presented]. For all pts., median survival time (MST) from first incurable metastasis was 12.7 mo., and median times to PD and MST from start of CXB were 3.3 mo. and 8.1 mo. respectively. Conclusion: CXB has clinical activity and merits further evaluation with parallel study of COX-2 expression in MMM to investigate its biologic basis. No significant financial relationships to disclose.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.002 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".