Cutaneous Manifestations of Cronkhite-Canada Syndrome -A Case Report-
Bibliographic record
Abstract
Cronkhite-Canada syndrome (CCS), first described by Cronkhite and Canada in 1955, is characterized by gastrointestinal polyposis, cutaneous hyperpigmentation, onychodystrophy and alopecia. As compared with complete form of full expression, the incomplete form may lack one or some of the clinical cutaneous manifestations. A 60-year-old Taiwanese man had chronic diarrhea and poor appetite with gradual weight loss over the past one year. Numerous discrete freckle-like macules were scattered over palms and soles, as well as the flexural sides of upper extremities. All the twenty digits, toenails in particular, were slightly clubbing in shape with dystrophic nails. Male-pattern baldness rather than diffuse hair loss was observed. Endoscopy and small bowel series disclosed numerous polyps of varying sizes from the stomach to descending colon; histopathology revealed juvenile polyps with focal adenomatous change. After subtotal colectomy, fingernails have regrown but toenails remained dystrophic. Freckle-like macules over palms, soles, and flexural sides of upper extremities faded and decreased in number, while hair loss was stable. We present this case of incomplete form of CCS, and discuss the differential diagnoses in dermatological aspect.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.001 |
| Meta-epidemiology (narrow) | 0.001 | 0.001 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.001 | 0.001 |
| Science and technology studies | 0.002 | 0.001 |
| Scholarly communication | 0.001 | 0.001 |
| Open science | 0.001 | 0.001 |
| Research integrity | 0.002 | 0.001 |
| Insufficient payload (model declined to judge) | 0.002 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".