Interactions between gonadal steroids and neonatal caffeine exposure on HVR in adult male rats
Bibliographic record
Abstract
Caffeine is commonly used to treat apnea in newborn infants, but the long‐term consequences of this treatment are poorly understood. We previously showed that neonatal caffeine treatment induces long lasting changes on respiratory control in adult male rats but not in females. To test the interaction of neonatal caffeine treatment and sexual hormone on respiratory pattern, adult male and female rats, that received by gavage either caffeine (15mg/kg/day – postnatal days 3–12) or water (control) were sham‐operated or gonadectomized. After 14 days of recovery, ventilatory parameters were measured under normoxia and in response to moderate hypoxia (12% O 2 – 20 min). In sham males, a significant interaction (treatment x hypoxia) was obtained for the increase in respiratory frequency (p<0.001) and the decrease in inspiratory time (p<0.01) in hypoxia. No interaction was obtained in gonadectomized rats. In females, no interaction between hypoxia and nicotine was observed in sham or ovarectomized rats. This suggests that endogenous circulating testosterone in adult males is necessary to reveal the alterations induced by caffeine on respiratory control. Supported by CIHR.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.001 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.001 | 0.000 |
| Science and technology studies | 0.000 | 0.001 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.003 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".