Progressive exercise training protects bone marrow stem cells from radiation‐induced damage
Bibliographic record
Abstract
Exercise training is known to induce an adaptive response in numerous tissues, however, the effects of exercise training on bone marrow stem cells (BMSC) is unknown. The purpose of this study was to determine if exercise training produced adaptations in BMSC and if this adaptive response could protect against subsequent high levels of ROS. C57Bl/6 mice were divided into the following groups (n=6 per group): treadmill running (EX), treadmill running and low dose radiation (ExLDR), and control (CON). Following 10 weeks of intervention half the mice in each group were exposed to a high dose radiation (HDR) challenge. Exercise training did not affect the basal number of double strand breaks (DSB) as determined by Gamma H2AX foci, but resulted in significantly fewer DSB in response to HDR, in vitro . Furthermore, exercise training significantly decreased both the basal number of micronucleated reticulocytes (MN‐RET) as well as the number of MN‐RET in response to HDR, in vivo . Interestingly, exercise was able to prevent the increase in basal MN‐RET in the mice exposed to 10 weeks of LDR. In conclusion, progressive exercise training was sufficient to protect BMSC from high doses of radiation. This research was funded by US DOE, Low Dose Research Program (DE‐FG02‐07ER64343) and NSERC.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.001 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".