Bibliographic record
Abstract
Unilateral tongue edema has rarely been reported in cases of acute ischemic stroke treated with tissue plasminogen activator (tPA).1,2 We present a case of hemilingual edema in acute stroke not associated with tPA.An 82-year old male with no prior history of stroke presented with forehead sparing right facial droop, mild weakness and ataxia of the right upper limb, dysarthria, dysphagia and significant right hemilingual edema.Electrocardiogram (EKG) showed atrial fibrillation and the international normalized ratio (INR) was 1.4.He was on warfarin, simvastatin, ramipril, metoprolol, levothyroxine, furosemide, and potassium chloride supplements.Head computed tomography (CT) showed an old lacune in the left lentiform nucleus and small hypodensity in the right internal capsule.The tongue edema and dysphagia took two and four days, respectively, to resolve.Examination 12 days post-stroke revealed improved right facial droop, and he was slow though not ataxic with finger-nose finger testing on the right.The right hemiparesis and gait difficulties had resolved.Tongue, palate and gag were normal.A mild right Horner's syndrome was noted (not commented on previously), which was later confimed by neuroophthalmology.Carotid dopplers showed no significant stenosis, with antegrade flow in both vertebral arteries.Brain magnetic resonance imaging (MRI) seven months post-stroke showed diffuse atrophy and non-specific white matter changes consistent with microvascular disease.There was no evidence of acute, subacute or chronic infarct on T1, T2, FLAIR or diffusion weighted images.Brain magnetic resonance angiogram (MRA) showed normal vertebral, basilar, internal and middle carotid arteries.Echocardiogram revealed mild bi-atrial enlargement and possible inferior septal hypokinesia, but no significant valvular abnormalities.His presentation was most consistent with a brainstem event, 3 likely from a cardioembolic source given his history of atrial fibrillation and subtherapeutic INR.Horner's syndrome ipsilateral to the limb and facial weakness is puzzling; it was not commented on initially but was likely missed.Lingual angioedema in acute ischemic stroke treated with tPA may be bilateral or unilateral, often contralateral to the affected hemisphere, with a greater risk in strokes affecting the insula or anterior frontal cortex. 1 All but one of the cases reported by Hill et al. 1 resolved within 1-24 hours.In our case, the lingual edema resolved within 48 hours.Interestingly, five of nine patients with angioedema were on both an angiotensin converting enzyme (ACE) inhibitor and a beta-blocker, 1 as was our patient.The mechanism of tPA associated lingual edema likely involves genetic factors such as bradykinin metabolism, and infarction location, as basal cardiac sympathetic tone was found to be maintained in the insular cortex. 1 Through tPA hydrolysis of plasminogen to plasmin, a bradykinin precursor is released, resulting in vasodilation.1 ACE inhibitors also increase the
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.003 |
| Meta-epidemiology (narrow) | 0.001 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.001 | 0.001 |
| Science and technology studies | 0.001 | 0.001 |
| Scholarly communication | 0.001 | 0.001 |
| Open science | 0.000 | 0.001 |
| Research integrity | 0.001 | 0.001 |
| Insufficient payload (model declined to judge) | 0.002 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".