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Record W2259815689 · doi:10.1038/nature16996

Real-time, portable genome sequencing for Ebola surveillance

2016· article· en· W2259815689 on OpenAlexafffund
Joshua Quick, Nicholas J. Loman, Sophie Duraffour, Jared T. Simpson, Ettore Severi, Lauren A. Cowley, Joseph Akoi Boré, Raymond Koundouno, Gytis Dudas, Amy Mikhail, Nobila Ouédraogo, Babak Afrough, Amadou Bah, Jonathan H. J. Baum, Beate Becker‐Ziaja, Jan Peter Boettcher, Mar Cabeza-Cabrerizo, Álvaro Camino-Sánchez, Lisa L. Carter, Juliane Doerrbecker, Theresa Enkirch, Isabel García-Dorival, Nicole Hetzelt, Julia Hinzmann, Tobias Holm, Liana E. Kafetzopoulou, Michel Koropogui, Abigael Kosgey, Eeva Kuisma, Christopher H. Logue, Antonio Mazzarelli, Sarah Meisel, Marc Mertens, Janine Michel, Didier Ngabo, Katja Nitzsche, Elisa Pallasch, Livia Victoria Patrono, Jasmine Portmann, Johanna Repits, Natasha Y. Rickett, Andreas Sachse, Katrin Singethan, Inês Vitoriano, Rahel L. Yemanaberhan, Elsa Gayle Zekeng, Trina Racine, Alexander Bello, Amadou Alpha Sall, Ousmane Faye, Oumar Faye, N’Faly Magassouba, C.V. Williams, Victoria Amburgey, Linda Winona, Emily Davis, Jon Gerlach, F Clarke -Washington, Vanessa Monteil, Marine Jourdain, Marion Bererd, Alimou Camara, Hermann Somlaré, Abdoulaye Camara, Marianne Gérard, Guillaume Bado, Bernard Baillet, Déborah Delaune, Koumpingnin Nebié, Abdoulaye Diarra, Yacouba Savane, Raymond Pallawo, Giovanna Jaramillo Gutierrez, Natacha Milhano, Isabelle Roger, Christopher J. Williams, Facinet Yattara, Kuiama Lewandowski, James G. Taylor, Phillip A. Rachwal, Daniel J. Turner, Georgios Pollakis, Julian A. Hiscox, David A. Matthews, Matthew K. O’ Shea, Andrew Johnston, Duncan Wilson, Emma Hutley, Erasmus Smit, Antonino Di, Roman Wölfel, Kilian Stoecker, Erna Fleischmann, Martin Gabriel, Simon A. Weller, Lamine Koivogui, Boubacar Diallo, Sakoba Keïta, Andrew Rambaut, Pierre Formenty, Stephan Günther, Miles W. Carroll

Bibliographic record

VenueNature · 2016
Typearticle
Languageen
FieldMedicine
TopicViral Infections and Outbreaks Research
Canadian institutionsPublic Health Agency of CanadaUniversity of TorontoOntario Institute for Cancer Research
FundersDirectorate-General for International Cooperation and DevelopmentMedical Research CouncilSurgical Reconstruction and Microbiology Research CentrePublic Health AgencyWorld Health OrganizationEuropean CommissionGovernment of OntarioDefence Science and Technology LaboratoryNational Institute for Health and Care ResearchPublic Health Agency of CanadaOxford Nanopore TechnologiesAfrican Union
KeywordsEbola virusGenomeBiologyDNA sequencingEbolavirusWhole genome sequencingNanopore sequencingGenomicsComputational biologyGeneticsOutbreakVirologyGene

Abstract

fetched live from OpenAlex
No abstract in any covered source. Its absence is recorded, not treated as a negative.

No abstract. This is not a gap in this database; OpenAlex has none either. 23.3% of the frame is in this state, and the screen finds HALF as much metaresearch here, so the absence is a measured bias rather than a missing field.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.001
metaresearch head score (Gemma)0.002
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Bench or experimental · Consensus signal: none
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.006
Threshold uncertainty score0.020

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0010.002
Meta-epidemiology (narrow)0.0010.000
Meta-epidemiology (broad)0.0010.001
Bibliometrics0.0010.001
Science and technology studies0.0010.000
Scholarly communication0.0010.001
Open science0.0010.001
Research integrity0.0010.001
Insufficient payload (model declined to judge)0.0060.002

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.017
GPT teacher head0.322
Teacher spread0.305 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designBench or experimental
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations1,555
Published2016
Admission routes2
Has abstractno

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