Interaction between cardiac heme oxygenase and natriuretic peptide system
Bibliographic record
Abstract
Genetic mouse models have recently shown that cardiac heme oxygenase (HO) and natriuretic peptide system (NPS) are essential for proper tissue dynamics and gene expression in the heart. However, the interaction between these two systems has not yet been investigated. The objective of this study was to determine the effect of ANP disruption on gene expression of the HO system, and to determine the effect of HO‐1 ablation and cardiac‐specific HO‐1 over‐expression on the NPS. Three mouse models were utilized: ANP −/− , HO −/− and HO‐1 cardiac‐specific transgenic (HO‐1 TG), and the respective wild‐type controls. Organs were excised, weighed, and snap‐frozen in liquid N 2 . Total RNA was extracted and analyzed by real‐time PCR. As expected, ANP −/− mice exhibited significant left ventricular hypertrophy. Surprisingly, HO‐1 −/− mice exhibited splenomegaly (almost three fold increase in spleen mass). There was no significant difference in ventricular HO‐2 mRNA expression in ANP −/− mice, however ventricular HO‐1 mRNA expression was significantly lower in ANP −/− mice compared to wild‐type controls. These data support the notion that HO and NPS interact with each other. The significance and the mechanism of splenomegaly in the HO −/− mice remain to be elucidated. Supported by the Heart and Stroke Foundation of Ontario.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".