Intermittent hypoxia induces neuroplasticity changes in the nucleus of the solitary tract (1132.1)
Bibliographic record
Abstract
Intermittent hypoxia (IH) is known to alter responses of neurons in NTS to cardiovascular afferent inputs. The mechanisms related for these IH effects in NTS may involve pre‐ or post‐synaptic neuroplasticity changes. To investigate this possibility, adult male Sprague‐Dawley rats were exposed to either 1‐, 7‐ or 95‐days of IH (8 h/day) or normoxia. Protein was extracted from NTS in each group of rats and analyzed by western blot for expression of brain‐derived neurotrophic factor (BDNF), tropomyosin kinase B (TrkB), synaptophysin and growth‐associated protein‐43 (GAP‐43). Arterial pressure (AP) and heart rate were not different between the IH and normoxic animals at 1‐ or 7‐days, but AP was elevated after 95‐days of chronic IH. After 1‐day IH, TrkB protein expression was higher and synaptophysin was lower than normoxic controls. After 7‐days of IH, BDNF and TrkB protein expression was higher in NTS. After 95‐days of chronic IH exposure, BDNF, synaptophysin, and GAP‐43 protein expression was lower in NTS. These results suggest that neuroplasticity changes occurring within NTS may be associated with the elevated AP induced by chronic IH activation of chemoreceptor afferents. Additionally, these data suggest that changes in neuroplasticity within NTS may contribute to the development of autonomic dysregulation often seen in patients with chronic obstructive sleep apnea. Supported by HSFO. Grant Funding Source : Heart and Stroke Foundation of Ontario
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".