Threonine Requirement in Neonates Receiving Total Parenteral Nutrition (TPN)
Bibliographic record
Abstract
Current neonatal threonine (THR) enteral requirement is 87 mg·kg‐1·d‐1. The THR requirement of the parenterally (TPN) fed human neonate has never been experimentally determined. Concentrations of THR in commercially available TPN solutions are derived from concentrations in cord blood, plasma amino acid profile during TPN feeding, or human milk, and are 30 to 80% higher than the enteral requirement. We showed in piglets that the neonatal TPN requirement for THR was 55% lower than the enteral requirement. Our objective was to determine the human neonatal TPN requirement for THR in post‐surgical neonates using the indicator amino acid oxidation technique with L[1–13C]phenylalanine. Neonates were randomized to receive one of twelve THR intakes ranging from 10 to 100 mg· kg‐1·d‐1. Preliminary data indicate a mean THR requirement between 30 and 40 mg·kg‐1·d‐1, only 30% of the THR concentration in the lowest THR containing TPN solution. We conclude that the THR requirement for TPN fed human neonates is significantly lower than the THR present in current TPN solutions and the recommended intake for orally fed infants. High THR intakes are a concern; THR is potentially neurotoxic and neonates are unable to oxidize excess
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.002 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".