Cyclotron produced Tc-99m on a TR24 high current target station
Bibliographic record
Abstract
1195 Objectives With the ongoing shortages in the availability of the key medical isotope, 99mTc, the potential of scaled up production of 99mTc is a prime concern. This work focuses on the target design modifications required for large scale production of 99mTc via the 100Mo(p,2n)99mTc reaction on a high current TR24 target station. Methods Approximately 1.4 g of enriched 100Mo was rolled, annealed, and bonded onto an aluminum target support plate. With a density in excess of 95%, the 100Mo had dimensions of 80 mm x 20 mm and an effective thickness of 0.72 mm (0.77 g/cm2), thereby capturing an energy window of 24 to 12 MeV. Multiple targets have been produced and two test irradiations at a nominal extraction energy of 24 MeV for 4 and 8 hours respectively, have been performed to date on the University of Alberta’s TR24 at 250 uA. Results The irradiated targets were assayed using a dose calibrator, with multiple measurements performed to estimate the contribution of 99mTc to the dose calibrator readings. Attenuation corrections within the 100Mo or aluminum target plate were not performed. Although target wear was noted in these initial preliminary irradiations, total productions of 0.31 TBq (8.4 Ci), and 0.46 TBq (12.4 Ci) 99mTc were realized. These results correspond to saturated yields of 3.4 and 3.0 GBq/uA, respectively. Conclusions This work demonstrates the first >10 Ci production of 99mTc on a TR24 cyclotron on our prototype high-current 100Mo targets. With the goal of reliable, large-scale production of 99mTc, further target modifications and testing at higher beam current are required. Research Support This work was supported by Natural Resources Canada’s Isotope Technology Acceleration Program (ITAP). We would also like to acknowledge our ITAP partners, Advanced Cyclotron Systems, Inc., and Centre Hospitalier Universitaire de Sherbrooke.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.001 | 0.001 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.001 | 0.000 |
| Open science | 0.001 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.013 | 0.003 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".