A novel function for neurexin and neuroligin family members in promoting neurite outgrowth
Bibliographic record
Abstract
ABSTRACT Neurexins and neuroligins are heterophilic cell adhesion molecules which interact with the cytoskeleton and play a role in synaptogenesis. However, they are also expressed prior to synapse formation, suggestive of additional functions. Other neuronally expressed cell adhesion molecules play a role in promoting neurite outgrowth in addition to their adhesive functions. Here, we demonstrate a novel role for neuroligin 1 in promoting neurite outgrowth in N1E-115 neuroblastoma cells. Further, we identify both the acetylcholinesterase-like domain and PDZ motif as essential requirements for this process. We demonstrate that neuroligin 2 and neurexin 1β can produce the cytoskeletal rearrangements required for neurite outgrowth in N1E-115 cells. Finally, we show expression of nlgn1, nlgn2, nrxn1 and nrxn2 in the developing murine spinal cord. Insight into the outgrowth-promoting effects of the neurexin-neuroligin complex is especially pertinent as defects in neurexin and neuroligin family members have been linked to the autism spectrum of neurodevelopmental disorders.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".