YJL185c encodes a peroxisomal protein that binds Inp1p and is required for peroxisome retention
Bibliographic record
Abstract
The inheritance of cellular organelles from mother cell to daughter cell is critical for eukaryotic cells to maintain the metabolic benefits of compartmentalization. Because of its asymetrical division, the budding yeast Saccharomyces cerevisiae has been used extensively to understand the molecular pathways involved in the inheritance of different organelles. The inheritance of peroxisomes is dependent on the peroxisomal protein Inp1p, which is directly involved in tethering peroxisomes to anchoring structures at the cell cortex. Although Inp1p is a major factor acting in the peroxisomal retention pathway, we proposed that its action in peroxisome retention is regulated by additional proteins. with which it interacts. A protein of unknown function encoded by the open reading frame YJL185c was shown to interact with Inp1p by the yeast two‐hybrid system. Cells deleted for YJL185c exhibit an altered peroxisome morphology and a preferred localization of peroxisomes to the bud neck. Yjl185p tagged with green fluorescent protein, GFP, shows both a peroxisomal and a weak cortical localization. Our studies help to clarify the mechanism of action of Inp1p in peroxisome inheritance and identify Yjl185p as a novel protein involved in peroxisome inheritance.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.001 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.001 | 0.001 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.001 | 0.000 |
| Research integrity | 0.001 | 0.001 |
| Insufficient payload (model declined to judge) | 0.002 | 0.002 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".