Linearity and stationarity of the pharmacokinetics of tiludronate in horses
Bibliographic record
Abstract
Two studies were conducted in order to assess the linearity and stationarity of the pharmacokinetics of tiludronate in horses. For each study, plasma concentrations of tiludronate were measured by HPLC-UV at regular intervals and noncompartmental analysis was performed. First, single intravenous administrations of 0.05 (group 1, n = 5), 0.1 (group 2, n = 5) and 0.2 mg/kg (group 3, n = 5) were performed in healthy male adult horses. A linear relationship between groups was found for C5min (C5min = 0.0726 + 11.8589 * dose) as well as for AUC0-inf (AUC0-inf = -0.632561 + 30.9649 * dose). Clearance ranged from 0.033 to 0.044 L/h/kg and was not significantly different between groups. MRT (h) were 3.96, 4.95 and 9.40 and VDss (L/kg) were 0.16, 0.19 and 0.28 for the 0.05, 0.1 and 0.2 mg/kg doses respectively. Second, 10 daily intravenous administrations at a dosage rate of 0.1 mg/kg were administered to 4 healthy horses. Plasma tiludronate concentrations were measured after the 1st and 10th dose as well as 8 hours after each dose. The mean plasma accumulation ratio between the 1st and the 10th dose was 1.31 ± 0.48. Medians of the tiludronate concentration values measured in plasma 8 hours post-dose were not statistically different between doses. Maximum and minimum concentrations of tiludronate (mg/L) following the last dose were 0.91 and 0.04 respectively. It was concluded that the pharmacokinetics of tiludronate in horses are linear from 0.05 to 0.2 mg/kg IV and stationary after 10 IV administrations of 0.1 mg/kg.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".