Pituitary and Ovarian Responses After an Application of a Low Therapeutic Dose of the LHRH-Lytic Peptide Conjugate During the Pre-Ovulatory Period in Ewes.
Bibliographic record
Abstract
The aim of this experiment was to determine the effects of a low therapeutic dose (0.2 mg/kg body weight i.v.) of an anti-cancer, lytic peptide conjugate, LHRH-Phor21, on the periovulatory ovarian and endocrine events, ensuing luteal function and fertility in an ovine experimental model. We hypothesized that the dense expression of LHRH receptors on the anterior pituitary and ovarian structures during the periovulatory period would make them highly susceptible to the membrane disrupting ability of LHRH-Phor21. Six sexually mature Rideau Arcott ewes were used to test the effects of the conjugate; seven ewes served as saline-injected controls. Prior to drug administration, estrus was synchronized with intravaginal progestogen-releasing sponges (medroxyprogesterone acetate, 60 mg) and a single i.m. injection of 750 IU of equine chorionic gonadotropin (eCG) given at sponge withdrawal. LHRH-Phor21 or saline were administered 36 h after eCG injection, around the expected onset of the endogenous discharge of gonadotropins. Treatment with LHRH-Phor21 resulted in an earlier rise (P<0.05) in estradiol production and greater (P<0.05) pre-ovulatory LH peak concentrations as compared to control ewes; however, there were no differences (P>0.05) in the mean number of ultrasonographically detected luteal structures and serum progesterone concentrations during the luteal phase post-treatment. There were no differences (P>0.05) in the number of ewes that lambed or lamb characteristics between the two groups at lambing 9 months post-treatment. Overall, there was no significant effect of GnRH-Phor21 on the ovulatory process, luteal function and lamb productivity post-treatment. With a lack of adverse effects of the LHRH-Phor21 on pituitary and ovarian function and fertility, our results support the safety of LHRH-Phor21 as a cancer pharmaceutical in reproductive-aged female patients. (poster)
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".