Effect of sugar cane policosanols on cholesterol metabolism and LDL oxidation in hypercholesterolemic individuals
Bibliographic record
Abstract
Sugar cane policosanols (SCP) purportedly exert cholesterol‐modulating properties including reductions in LDL oxidation and cholesterol synthesis, as shown by a Cuban research group. However, independent research examining LDL oxidation and cholesterol synthesis is limited to very few studies contradicting outcomes of original research. Moreover, no data are available on the effect of SCP on cholesterol absorption to date. Therefore, objectives of the present study were to examine the effect of Cuban SCP on LDL oxidation, and to determine the changes in cholesterol kinetics in hypercholesterolemic individuals. Twenty‐one subjects participated in a randomized double blind crossover where they consumed 10 mg/day of policosanols or placebo incorporated in margarine during 28 days. Cholesterol absorption and synthesis were measured using 13 C labelled cholesterol and deuterium water respectively, administered the last week of each phase. Plasma LDL oxidation was measured using a solid phase two site enzyme immunoassay. Results show no difference in endpoint oxidized LDL concentrations between SCP and placebo treatments. Similarly, absorption and synthesis rates did not differ between groups. Our results demonstrate that SCP fail to alter LDL oxidation status and cholesterol metabolism.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".