Identification CD79a and CD79b homologs in channel catfish, Ictaulurus punctatus
Bibliographic record
Abstract
The catfish (Ip) B cell receptor accessory molecules CD79a and CD79b homologs have been identified. Each are encoded by single copy genes that encode proteins containing a signal peptide, an extracellular immunoglobulin domain, a transmembrane region and a cytoplasmic tail containing an immunoreceptor tyrosine kinase activation motif (ITAM). At the message level, both IpCD79a and IpCD79b correlate well with IgM message expression since they are highly expressed in membrane IgM + peripheral blood leukocytes (PBL) and in catfish clonal B cell lines, but not in IgM − PBL or in clonal T cells or macrophages. Such findings indicate that IpCD79a and IpCD79b expression is B cell restricted. Furthermore, studies using catfish clonal B cells (3B11) transfected with constructs encoding epitope‐tagged IpCD79 proteins revealed that IpCD79a is expressed as a 45 kDa protein and IpCD79b is expressed as a 32 kDa protein. These correlate with the molecular weights of putative tyrosine phosphorylated accessory proteins that are co‐immunoprecipitated with surface IgM following anti‐Ig stimulation. Supported by NIH grant R01 AI19530 .
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.001 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.001 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".