MétaCan
Menu
Back to cohort
Record W2282045679 · doi:10.1385/0-89603-122-5:49

Neurotoxins That Affect Central Indoleamine Neurons

2003· book-chapter· en· W2282045679 on OpenAlexaff
Tombs A. Reader

Bibliographic record

VenueHumana Press eBooks · 2003
Typebook-chapter
Languageen
FieldNeuroscience
TopicNeurotransmitter Receptor Influence on Behavior
Canadian institutionsUniversité de Montréal
Fundersnot available
KeywordsSerotoninCentral nervous systemNeurotransmitterNeuroscienceBiogenic amineChemistryTryptophanBiologyBiochemistryAmino acid

Abstract

fetched live from OpenAlex

The indoleamme serotonin (5-hydroxytryptamine, 5-HT) was described in the central nervous system (CNS) more than 30 years ago (Amin et al., 1954; Bogdanski et al., 1956; De Robertis, 1964; Twarog and Page, 1953; Zieher and De Robertis, 1963) based on biochemical determinations of this amine in different brain regions. These studies were rapidly followed by the use of histofluorescent microscopy (Anden et al., 1965, 1966, 1967; Dahlstrom and Fuxe, 1964; Fuxe, 1965; Moore et al., 1978; Ungerstedt, 1971) and measurements of the activity of tryptophan hydroxylase and 5-HT uptake (Kuhar et al., 1972). This work was later complemented by anatomical descriptions of the now chemically identified neurotransmitter systems using radioautographic tracing techniques that take advantage of the uptake properties of the 5-HT system (Azmitia, 1978; Azmitia and Segal, 1978; Beaudet and Descarrres, 1981, Parent et al, 1981) as well as by the use of immunocytochemrcal methods with antibodies against 5-HT itself (Steinbusch, 1981, Steinbusch et al , 1978; Steinbusch and Nreuwenhuys, 1983).

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.000
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesMeta-epidemiology (narrow)
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Not applicable · Consensus signal: none
GenreCandidate signal: Other · Consensus signal: Other
Teacher disagreement score0.663
Threshold uncertainty score0.999

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0000.000
Meta-epidemiology (narrow)0.0010.001
Meta-epidemiology (broad)0.0010.001
Bibliometrics0.0000.000
Science and technology studies0.0000.001
Scholarly communication0.0000.000
Open science0.0020.000
Research integrity0.0010.002
Insufficient payload (model declined to judge)0.0010.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.132
GPT teacher head0.295
Teacher spread0.162 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one teacher head, not a consensus.

Study designNot applicable
Domainnot available
GenreOther

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations14
Published2003
Admission routes1
Has abstractyes

Explore more

Same venueHumana Press eBooksSame topicNeurotransmitter Receptor Influence on BehaviorFrench-language works237,207