Olanzapine-Induced Diabetic Ketoacidosis Resulting in Prolongation of Hospital Stay: Clinical Outcome and Cost Issues
Bibliographic record
Abstract
INTRODUCTION A typical antipsychotics are as effective as traditional antipsychotics in the treatment of chronic psychotic disorders and are associated with fewer extrapyramidal symptoms.1 Despite their lower propensity to induce extrapyramidal symptoms, these drugs are associated with other adverse effects, including anticholinergic effects, hypotension, sedation, sexual dysfunction, and weight gain.2 Endocrine disturbances such as hyperglycemia, new-onset type 2 diabetes mellitus, and ketoacidosis have been associated with atypical antipsychotics, including olanzapine.3 Diabetic ketoacidosis is a serious, potentially lifethreatening metabolic complication of diabetes mellitus.4 Numerous cases of this adverse effect have been reported during treatment with clozapine and olanzapine, but fewer case reports have been published for risperidone and quetiapine.3 We report a case of prolonged hospital stay resulting from olanzapineinduced diabetic ketoacidosis in a patient with no previous personal or family history of diabetes. This case illustrates the substantial morbidity associated with this adverse effect.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.003 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.001 |
| Bibliometrics | 0.001 | 0.001 |
| Science and technology studies | 0.001 | 0.000 |
| Scholarly communication | 0.001 | 0.000 |
| Open science | 0.000 | 0.001 |
| Research integrity | 0.001 | 0.001 |
| Insufficient payload (model declined to judge) | 0.002 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".