Dysfunction of endothelial and smooth muscle cells in small arteries of a mouse model of Marfan syndrome
Bibliographic record
Abstract
Marfan syndrome, a connective tissue disorder caused by mutations in FBN1 encoding fibrillin‐1, results in life‐threatening complications in the aorta, but little is known about its effects in resistance vasculature. Second‐order mesenteric arteries from mice at 3, 6, and 10 months of age heterozygous for the Fbn1 allele encoding a cysteine substitution ( Fbn1 C1039G/+ ) were compared with those from age‐matched control littermates. Stress‐strain curves indicated that arterial stiffness was increased at 6 and 10 months of age in Marfan vessels. Isometric force measurement revealed that contraction in response to high potassium‐induced membrane depolarization was significantly decreased in Marfan vessels at all ages, while both phenylephrine‐induced contraction and frequency of Ca 2+ oscillations was reduced by at least 40% from 6 months onward. In addition, both endothelium‐dependent and endothelium‐independent relaxation to acetylcholine and sodium nitroprusside, respectively, was also reduced starting at 6 months of age. We conclude that pathogenesis of Marfan syndrome in resistance‐sized arteries increases stiffness and impairs vasomotor function. This work was funded by CIHR of Canada.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.001 | 0.001 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.001 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.001 | 0.001 |
| Insufficient payload (model declined to judge) | 0.002 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".