A Meta-Analysis of Exhaled Nitric Oxide in Acute Normobaric Hypoxia
Why this work is in the frame
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Bibliographic record
Abstract
BACKGROUND: The effect of hypoxia on the exhaled nitric oxide (NO) of humans is unresolved. Many studies have measured the fraction of exhaled NO (FENO) or the partial pressure of exhaled NO (PENO) in normobaric and hypobaric hypoxia, with differing results. METHODS: To better understand NO physiology and altitude acclimatization, we employed a random effects meta-analysis to determine the effect of acute normobaric hypoxia on the PENO of humans. A total of 93 subjects from 7 published studies (with 9 groups) were included. The median duration of exposure was 30 min and the mean hypoxic PIo2 was 95 (SD=10) mmHg. RESULTS: The weighted standardized mean difference (SMD) in PENO measured at baseline and during an acute exposure to normobaric hypoxia was not significantly different from zero (SMD=0.09; 95% CI=-0.17, 0.34; z=0.65). CONCLUSION: Based on this meta-analysis, acute normobaric hypoxia does not affect the PENO measured from the mouths of humans. This result should be considered for interpretations of high-altitude (and hypobaric) measurements of exhaled NO. As the PENO is a potential biomarker for altitude-illness susceptibility, recognizing that normobaric hypoxia does not affect the PENO will be important for understanding previous associations between low exhaled NO and poor acclimatization to hypoxia.
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Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.000 |
| Meta-epidemiology (narrow) | 0.001 | 0.000 |
| Meta-epidemiology (broad) | 0.004 | 0.001 |
| Bibliometrics | 0.001 | 0.001 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it