← Back to cohort
New loci for body fat percentage reveal link between adiposity and cardiometabolic disease risk
Yingchang Lu, Felix R. Day, Stefan Gustafsson, Martin L. Buchkovich, Jianbo Na, Véronique Bataille, Diana L. Cousminer, Zari Dastani, Alexander Drong, Tõnu Esko, David M. Evans, Mario Falchi, Mary F. Feitosa, Teresa Ferreira, Åsa K. Hedman, Robin Haring, Pirro G. Hysi, Mark M. Iles, Anne E. Justice, Stavroula Kanoni, Vasiliki Lagou, Rui Li, Xin Li, Adam E. Locke, Lu Chen, Reedik Mägi, John R. B. Perry, Tune H. Pers, Qibin Qi, Marianna Sanna, Ellen M. Schmidt, William R. Scott, Dmitry Shungin, Alexander Teumer, Anna A. E. Vinkhuyzen, Ryan W. Walker, Harm-Jan Westra, Mingfeng Zhang, Weihua Zhang, Wei Zhao, Zhihong Zhu, Uzma Afzal, Tarunveer S. Ahluwalia, Stephan J. L. Bakker, Claire Bellis, Amélie Bonnefond, Katja Borodulin, Aron S. Buchman, Tommy Cederholm, Audrey C. Choh, Hyung Jin Choi, Joanne E. Curran, C.P.G.M. de Groot, Philip L. De Jager, R.A.M. Dhonukshe-Rutten, Anke W. Enneman, Elodie Eury, Daniel S. Evans, Tom Forsén, Nele Friedrich, Frédéric Fumeron, Melissa E. Garcia, Simone Gärtner, Bok‐Ghee Han, Aki S. Havulinna, Caroline Hayward, Dena Hernández, Hans L. Hillege, Till Ittermann, Jack W. Kent, Ivana Kolčić, Tiina Laatikainen, Jari Lahti, Irene Mateo Leach, Christine G. Lee, Jong‐Young Lee, Tian Liu, Youfang Liu, Stéphane Lobbens, Marie Loh, Leo‐Pekka Lyytikäinen, Carolina Medina‐Gómez, Karl Michaëlsson, Mike A. Nalls, Carrie M. Nielson, Laticia Oozageer, Laura Pascoe, Lavinia Paternoster, Ozren Polašek, Samuli Ripatti, Mark A. Sarzynski, Chan Soo Shin, Nina Smolej Narančić, Dominik Spira, Priya Srikanth, Elisabeth Steinhagen–Thiessen, Karin M. A. Swart, Leena Taittonen, Toshiko Tanaka, Emmi Tikkanen, Nathalie van der Velde, Natasja M. van Schoor, Niek Verweij, Alan F. Wright, Lei Yu, Joseph M. Zmuda, Niina Eklund, Terrence Forrester, Niels Grarup, Anne Jackson, Kati Kristiansson, Teemu Kuulasmaa, Johanna Kuusisto, Peter Lichtner, Jian’an Luan, Anubha Mahajan, Satu Männistö, Cameron D. Palmer, Janina S. Ried, Robert A. Scott, Alena Stančáková, Peter J. Wagner, Ayşe Demirkan, Angela Döring, Vilmundur Guðnason, Douglas P. Kiel, Brigitte Kühnel, Massimo Mangino, Barbara McKnight, Cristina Menni, Jeffrey R. O’Connell, Ben A. Oostra, Alan R. Shuldiner, Kijoung Song, Liesbeth Vandenput, Cornelia M. van Duijn, Péter Vollenweider, Charles C. White, Michael Boehnke, Yvonne Boettcher, Nita G. Forouhi, Christian Gieger, Harald Grallert, Aroon D. Hingorani, Torben Jørgensen, Pekka Jousilahti, Mika Kivimäki, Meena Kumari, Markku Laakso, Claudia Langenberg, Allan Linneberg, Amy Luke, Colin A. McKenzie, Aarno Palotie, Oluf Pedersen, Annette Peters, Konstantin Strauch, Bamidele O. Tayo, Nicholas J. Wareham, David A. Bennett, Lars Bertram, John Blangero, Matthias Blüher, Claude Bouchard, Harry Campbell, Nam H. Cho, Steven R. Cummings, Stefan A. Czerwinski, Ilja Demuth, Rahel Eckardt, Johan G. Eriksson, Luigi Ferrucci, Oscar H. Franco, Philippe Froguel, Ron T. Gansevoort, Torben Hansen, Tamara B. Harris, Nicholas D. Hastie, Markku Heliövaara, Albert Hofman, Joanne M. Jordan, Antti Jula, Mika Kähönen, Eero Kajantie, Paul Knekt, Seppo Koskinen, Péter Kovács, Terho Lehtimäki, Lars Lind, Ching‐Ti Liu, Eric Orwoll, Clive Osmond, Markus Perola, Louis Përusse, Olli T. Raitakari, Tuomo Rankinen, D. C. Rao, Treva Rice, Fernando Rivadeneira, Igor Rudan, Veikko Salomaa, Thorkild I. A. Sørensen, Michael Stümvoll, Anke Tönjes, Bradford Towne, Gregory J. Tranah, Angelo Tremblay, André G. Uitterlinden, Pim van der Harst, Erkki Vartiainen, Jorma SA Viikari, Véronique Vitart, Marie‐Claude Vohl, Henry Völzke, Mark Walker, Henri Wallaschofski, Sarah H. Wild, James F. Wilson, Loïc Yengo, D. Timothy Bishop, Ingrid B. Borecki, John C. Chambers, L. Adrienne Cupples, Abbas Dehghan, Panos Deloukas, Ghazaleh Fatemifar, Caroline S. Fox, Terrence S. Furey, Lude Franke, Jiali Han, David J. Hunter, Juha Karjalainen, Fredrik Karpe, Robert C. Kaplan, Jaspal S. Kooner, Mark I. McCarthy, Joanne M. Murabito, Andrew P. Morris, Julia Newton‐Bishop, Kari E. North, Claes Ohlsson, Ken K. Ong, Inga Prokopenko, J. Brent Richards, Eric E. Schadt, Tim D. Spector, Elisabeth Widén, Cristen J. Willer, Jian Yang, Erik Ingelsson, Karen L. Mohlke, Joel N. Hirschhorn, J. Andrew Pospisilik, M. Carola Zillikens, Cecilia M. Lindgren, Tuomas O. Kilpeläinen, Ruth J. F. Loos
Bibliographic record
VenueNature Communications · 2016
Typereview
Languageen
FieldBiochemistry, Genetics and Molecular Biology
TopicGenetic Associations and Epidemiology
Canadian institutionsUniversité LavalCentre for Global Health ResearchMcGill UniversityJewish General Hospital
FundersNational Center for Advancing Translational SciencesNational Institute of Arthritis and Musculoskeletal and Skin DiseasesNational Institute of Neurological Disorders and StrokeNational Institute on AgingMünchner Zentrum für GesundheitswissenschaftenNetherlands Heart InstituteDanish Agency for Science and Higher EducationNational Institute of Food and AgricultureNational Institutes of HealthH. Lundbeck A/SHjartaverndVersus ArthritisNational Institute of Diabetes and Digestive and Kidney DiseasesTurun Yliopistollinen KeskussairaalaBoehringer Ingelheim StiftungOrionin TutkimussäätiöMedical Research CouncilUppsala UniversitetTampereen TuberkuloosisäätiöSydäntutkimussäätiöPaavo Nurmen SäätiöAkademiska SjukhusetDanmarks Frie ForskningsfondVetenskapsrådetCentre for Medical Systems BiologyLi Ka Shing FoundationNovo NordiskAgence Nationale de la RechercheHjärt-LungfondenDeutsche ForschungsgemeinschaftNederlandse Organisatie voor Wetenschappelijk OnderzoekRegion HovedstadenKuopion Yliopistollinen SairaalaNational Center for Research ResourcesCenters for Disease Control and PreventionNierstichtingBritish Heart FoundationBundesministerium für Bildung und ForschungRussian Foundation for Basic ResearchSuomen KulttuurirahastoMinisterie van Economische Zaken, Landbouw en InnovatieDiabetestutkimussäätiöBritish Skin FoundationZonMwInstitut National de la Santé et de la Recherche MédicaleKelaSchool of Medicine, Boston UniversityAstraZenecaEuropean CommissionTerveyden ja hyvinvoinnin laitosKing's College LondonCanadian Institutes of Health ResearchDiabetes UKLastentautien TutkimussäätiöNational Institute for Health and Care ResearchNederlandse Zuivel OrganisatieErasmus Medisch CentrumVrije Universiteit AmsterdamStiftelsen för Strategisk ForskningHealth and Safety ExecutiveWageningen University and ResearchCancer Research UKWellcome TrustU.S. Department of AgricultureSchweizerischer Nationalfonds zur Förderung der Wissenschaftlichen ForschungEmil Aaltosen SäätiöU.S. Department of Veterans AffairsLundbeckfondenLes Laboratories Pierre FabreJohn D. and Catherine T. MacArthur FoundationNational Heart, Lung, and Blood InstituteBiotechnology and Biological Sciences Research CouncilItä-Suomen YliopistoFoundation for Cardiovascular ResearchSigne ja Ane Gyllenbergin SäätiöGlaxoSmithKlineScottish GovernmentForsknings- og InnovationsstyrelsenFondation de FranceSundhed og Sygdom, Det Frie ForskningsrådClinical Science Research and DevelopmentNational Science FoundationJuho Vainion SäätiöNovo Nordisk FondenAmerican Heart Association
KeywordsLink (geometry)DiseaseMedicineEnvironmental healthBiologyInternal medicineGeneticsBioinformaticsComputer science
Abstract
To increase our understanding of the genetic basis of adiposity and its links to cardiometabolic disease risk, we conducted a genome-wide association meta-analysis of body fat percentage (BF%) in up to 100,716 individuals. Twelve loci reached genome-wide significance (P<5 × 10(-8)), of which eight were previously associated with increased overall adiposity (BMI, BF%) and four (in or near COBLL1/GRB14, IGF2BP1, PLA2G6, CRTC1) were novel associations with BF%. Seven loci showed a larger effect on BF% than on BMI, suggestive of a primary association with adiposity, while five loci showed larger effects on BMI than on BF%, suggesting association with both fat and lean mass. In particular, the loci more strongly associated with BF% showed distinct cross-phenotype association signatures with a range of cardiometabolic traits revealing new insights in the link between adiposity and disease risk.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.001
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesMeta-epidemiology (narrow)
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Not applicable · Consensus signal: none
GenreCandidate signal: Review · Consensus signal: Review
Teacher disagreement score0.967
Threshold uncertainty score1.000
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.001 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.001 | 0.001 |
| Research integrity | 0.001 | 0.001 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
Opus teacher head0.030
GPT teacher head0.360
Teacher spread0.330 · how far apart the two teachers sit on this one work
Validation status
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
Study designNot applicable
Domainnot available
GenreReview
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".
Quick stats
Citations316
Published2016
Admission routes2
Has abstractyes